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KMID : 0882420090770050643
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Korean Journal of Medicine
2009 Volume.77 No. 5 p.643 ~ p.648
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A case of peripheral T-cell lymphoma with central nervous system and bilateral pulmonary involvement
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Koo Tai-Yeon
Choi Jung-Hye
Kim In-Soon
Kim Hye-Young
Kim Won-Jun
Park Byeong-Bae
Lee Young-Yeul
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Abstract
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Mature T-cell non-Hodgkin’s lymphoma (NHL) has more frequent extranodal involvement and is less sensitive to chemotherapy than B-cell lymphoma. Peripheral T-cell lymphoma unspecified (PTCL-U) is rarely combined with pulmonary or CNS involvement. We report a case of PTCL-U with lung and CNS involvement that was treated with high-dose chemotherapy followed by autologous stem cell transplantation (ASCT). A 62-year-old man was admitted with right-side weakness and paresthesias, and was diagnosed with PTCL-U after alung biopsy. Successful complete remission was achieved after threecycles of IMEP(ifosfamide, methotrexate, etoposide, and prednisone) chemotherapywith concurrent intrathecal chemotherapy and subsequent high-dose chemotherapy with ASCT to treat potential advanced stage PTCL-U. The non-anthracycline-containing IMEP regimen can be effective for PTCL-U, especially in cases with CNS involvement.
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KEYWORD
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Peripheral T-cell lymphoma, Central nervous system and lung, MEP, Stem cell transplantation
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